MGMT/MLH1 Methylation Crystal Digital PCR® Assay
Assay-specific Crystal Flex Probes and primers for the detection of MGMT and MLH1 promoter methylation and its Positive Control.
For Research Use Only. Not for use in diagnostic procedures.
Compatibility
Channels
Required Reagents
The MGMT/MLH1 Methylation Crystal Digital PCR® Assay is a 10X assay designed to detect and quantify methylation in the promoters of the MGMT and MLH1 genes using the Ruby Chip. Both genes play critical roles in DNA repair mechanisms: MGMT is involved in the direct reversal of DNA alkylation damage, while MLH1 is a key component of the mismatch repair (MMR) pathway.
Promoter hypermethylation is the most common mechanism of gene silencing for both, leading to loss of function. This epigenetic inactivation contributes significantly to genomic instability and uncontrolled cell proliferation in a variety of cancers.
This assay is available in 200 and 1000 reaction formats.
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Ready-to-use  assay reagents to detect multiple targets in a single reaction
Crystal Flex Probe detection chemistry for flexible assay configuration
Same set of Crystal Universal Reporters to detect any target in different  assays
MGMT & MLH1 promoter methylation
Ready-to-use assays & kits
Explore our catalogue of assays and kits and take a leap into the world of multiplexing. Crystal Digital PCR® assays and kits allow for the detection of multiple targets of interests within one single Ruby Chip chamber.
Rapid high-plex assay customization
Stilla offers the fastest assay design service in the market for multiplexed digital PCR assays. Stilla exploits its proprietary Crystal Flex Probe PCR chemistry to offer customized assays in record time, at competitive prices.
